The research group of N. Rhodus has recently performed a first step in this direction.⁸⁰ They reported that change of NF-kB dependent cytokines (TNF-α, IL- 1, IL- 6 IL- 8) in saliva may in part reflect the malignant transformation of OLP and suggested that analysis of these cytokines may provide a useful, non-invasive surrogate endpoint for monitoring malignant transformation.⁸⁰ However, further studies are required to support these findings and to correlate the level of NF-kB dependent cytokines to the stage of malignant transformation of OLP.

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