Improved metabolic control, clinical periodontal status and 26. Taylor GW. Bidirectional interrelationships between diabetes subgingival microbiology in insulin-dependent diabetes mellitus. and periodontal diseases: an epidemiologic perspective. Ann A prospective study. J Clin Periodontol 1990;17:233-242. Periodontol 2001;6:99-112.

6. Stewart JE, Wager KA, Friedlander AH, Zadeh HH. The effect of 27. Geerts SO, Legrand V, Charpentier J, Albert A, Rompen EH. Further periodontal treatment on glycemic control in patients with type 2 evidence of the association between periodontal conditions and diabetes mellitus. J Clin Periodontol 2001;28:306-310. coronary artery disease. J Periodontol 2004;75:1274-1280.

7. Kiran M, Arpak N, Unsal E, Erdogan MF. The effect of improved 28. Southerland JH, Taylor GW, Moss K, Beck JD, Offenbacher S. periodontal health on metabolic control in type 2 diabetes Commonality in chronic inflammatory diseases: periodontitis, mellitus. J Clin Periodontol 2005;32:266-272. diabetes, and coronary artery disease. Ann Periodontol 2006.

8. LÖe H. Periodontal disease. The sixth complication of diabetes 40:130-143. mellitus. Diabetes Care 1993;16:329-334. 29. Feig, D. S., A. Razzaq, K. Sykora, J. E. Hux, and G. M. Anderson. 2006.

9. Kunzel C, Lalla E, and Lamster IB. Management of the patient who Trends in deliveries, prenatal care, and obstetrical complications smokes and the diabetic patient in the dental office. J Periodontol in women with pregestational diabetes: a population-based study 2006;77:331-340. in Ontario, Canada, 1996-2001. Diabetes Care 2006;29:232-235.

10. Standards of medical care in diabetes--2006. Diabetes Care 2006; 30. Robertson C, Drexler AJ, Vernillo AT. Update on diabetes diagnosis 29 Suppl 1:S4-42. and management. J Am Dental Assoc 2003;134:16S- 23.

11. Centers for Disease Control and Prevention. National diabetes fact 31. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-sheet: general information and national estimates on diabetes in glucose control with sulphonylureas or insulin compared with the United States, 2005. U.S.Department of Health and Human conventional treatment and risk of complications in patients with Services, Centers for Disease Control and Prevention, Atlanta, GA. type 2 diabetes (UKPDS 33). Lancet 1998;352:837-853.

2005 Ref Type: Electronic Citation. 32. UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive 12. Economic consequences of diabetes mellitus in the U.S. in 1997. blood-glucose control with metformin on complications in

American Diabetes Association. Diabetes Care 1998;21:296-309 overweight patients with type 2 diabetes (UKPDS 34). Lancet 13. CDC: 2005 National Diabetes Fact Sheet: Data & Trends, National 1998;352:854-865.

Diabetes Surveillance System, Prevalence of Cardiovascular 33. Retinopathy and nephropathy in patients with type 1 diabetes Disease. CDC: National Center for Chronic Disease Prevention four years after a trial of intensive therapy. The Diabetes Control and Health Promotion, Available at: http://www.cdc.gov/diabetes/ and Complications Trial/Epidemiology of Diabetes Interventions statistics/prev/national/ figpersons.htm. 2005 Ref Type: Electronic and Complications Research Group. N Engl J Med 2000;342:381- Citation. 389.

14. Saito T, Shimazaki Y, and Sakamoto M. Obesity and periodontitis. 34. Lawson ML, Gerstein HC, Tsui E, Zinman B. Effect of intensive N Engl J Med 1998;339:482-483. therapy on early macrovascular disease in young individuals with

15. Nishida N, Tanaka M, Hayashi N, et al. Determination of smoking type 1 diabetes. A systematic review and meta-analysis. Diabetes and obesity as periodontitis risks using the classification and Care 1999; 22 Suppl 2:B35-B39.

regression tree method. J Periodontol 2005;76:923-928. 35. Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia
16. Mealey BL, Moritz AJ. Hormonal influences: effects of diabetes with macrovascular and microvascular complications of type 2
mellitus and endogenous female sex steroid hormones on the diabetes (UKPDS 35): prospective observational study. Brit Med J
periodontium. J Periodontol 2000;32:59-81. 2000;321:405-412.
17.Armitage, GC. Development of a classification system for 36. Selvin E, Marinopoulos S, Berkenblit G, et al. Meta-analysis:
periodontal diseases and conditions. Ann Periodontol 1999;4: 1-6. glycosylated hemoglobin and cardiovascular disease in diabetes
18. Sbordone LL, Ramaglia A, Barone RN, et al. Periodontal status and mellitus. Ann Intern Med 2004;141:421-431.
subgingival microbiota of insulin-dependent juvenile diabetics: a 37. Sacks DB, Bruns DE, Goldstein DE, Maclaren NK, McDonald
3-year longitudinal study. J Periodontol 1998;69:120-128. JM, Parrott M. Guidelines and recommendations for laboratory

19. Cianciola L J, Park BH, Bruck E, Mosovich L, Genco RJ. Prevalence analysis in the diagnosis and management of diabetes mellitus. of periodontal disease in insulin-dependent diabetes mellitus Clin Chem 2002;48:436-472.

(juvenile diabetes). J Am Dent Assoc 1982;104:653-660. 38. Al-Ghazi MN, Ciancio SG, Aljada A, et al. Evaluation of Efficacy

20. de Pommereau V, Dargent-Pare C, Robert JJ, Brion M. Periodontal of Administration of Sub-antimicrobial-dose Doxycycline in the status in insulin-dependent diabetic adolescents. J Clin Periodontol Treatment of Generalized Adult Periodontitis in Diabetics. J Dent 1992;19:628-632. Res 2006;82[Spec Iss A] [abstract].

21. Cutler CW, Machen RL, Jotwani R, Iacopino AM. Heightened 39. Engebretson SP, Hey-Hadavi J, Celemti R, Lamster, IB. Low-dose gingival inflammation and attachment loss in type 2 diabetics Doxycycline Treatment Reduces Glycosylated Hemoglobin in with hyperlipidemia. J Periodontol 1999;70:1313-1321. Patients with Type 2 Diabetes: a Randomized Controlled Trial. J

22. Gusberti FA, Syed SA, Bacon G, Grossman N , Loesche WJ. Puberty Dent Res 82[Spec Iss A], [abstract] no. 1445. 2003.
gingivitis in insulin-dependent diabetic children. I. Cross-sectional 40. Taylor GW, Burt BA, Becker MP, et al. Severe periodontitis and risk
observations. J Periodontol 54:714-720; 1983. for poor glycemic control in patients with non-insulin-dependent
23. Ervasti T, Knuuttila M, Pohjamo L, Haukipuro K. Relation diabetesmellitus. J Periodontol 1996;67:1085-1093.
between control of diabetes and gingival bleeding. J Periodontol 41. Ebersole JL, Machen RL, Steffen MJ, Willmann DE. Systemic
1985;56:154-157. acute-phase reactants, C-reactive protein and haptoglobin, in
24. Karjalainen KM, Knuuttila ML. The onset of diabetes and poor adult periodontitis. Clin Exp Immunol. 1997;107:347-352.
metabolic control increases gingival bleeding in children and
adolescents with insulin-dependent diabetes mellitus. J Clin

Periodontol 1996;23:1060-1067.

25.Salvi GE, Kandylaki M, Troendle A, Persson GR, Lang NP. Experimental gingivitis in type 1 diabetics: a controlled clinical and microbiological study. J Clin Periodontol 2005;32:310-316.

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