Think all toothpastes

work the same?

Take a deeper look.

Colgate Total^®is proven to fight oral inflammation. Scientific evidence has linked oral inflammation to systemic health diseases such as cardiovascular and other diseases throughout the body^1-4

Only Colgate Total^® contains triclosan, and only triclosan
fights oral inflammationin 2 important ways^{1-3, 5, 6}

Kills plaque bacteria for a full 12 hours⁵

Up to 98% More Plaque Reduction^{1, 2}*; up to 88% More Gingivitis Reduction^{1, 2}*

- 10

% Reduction Compared With Control

- 20

- 30

- 40

- 50

-60

-70

-80

-90

-100

Plaque Gingivitis

Reduces the level of inflammatory mediators
that may play a role in systemic health^{3, 4}

70% Reduction in PGE ^6† ₂—a Key Mediator

33.0

PGE ³ ₂ (pg/10 Cells)

70%

2.0 Reduction 1.0

0.0

Control Triclosan

( 1 g/mL)

“Recent evidence suggests a strong relationship between periodontal inflammatory disease and systemic diseases
such as cardiovascular disease. It is now generally accepted that inflammation plays an important role…” ⁷
—Sheilesh, et al. Compendium. 2004.

12-Hour Antibacterial plus Anti-inflammatory Protection for Better Oral and Overall Health

Visit colgateprofessional.com for free patient samples. Colgate Total^® is the only FDA-approved toothpaste for plaque and gingivitis.
1. Volpe AR, et al. J Clin Dent. 1996; 7(suppl):S1-S14. 2. Davies RM, et al. J Clin Periodontol. 2004;31:1029-1033. 3. Gaffar A, et al. J Clin Periodontol. 1995;22:480-484. 4. Scannapieco FA. Compendium. 2004; 7(suppl 1): 16-25. 5. Amornchat C, et al.
Mahidol Dent J. 2004;24:103-111. 6. Modéer T, et al. J Clin Periodontol. 1996;23:927-933. 7. Sheilesh D, et al. Compendium. 2004; 7(suppl 1): 26-37.
*vs ordinary fluoride toothpaste. ^†in vitro.
©2005 Colgate-Palmolive Company C53248 7/05